- Type Disease
Nervous System
- Name
Lissencephaly
- Abbreviation
LSPHx
- Description
In this condition there is abnormal development of the nerve cells in the brain before birth. Pups with lissencephaly develop seizures, visual deficits (blindness) and unusual behaviors.
- How Transferred
unknown.
- What to Look for
The signs that are seen with this rare condition become evident shortly after birth. There are behavioral abnormalities (which can be severe), and the pups develop seizures and are blind.
- Diagnosis
Your veterinarian may suspect this condition based on the clinical signs and absence of abnormalities on routine diagnostic tests. The diagnosis can be confirmed by MRI (magnetic resonance imaging) or on post-mortem.
- Treatment
There is no treatment.
- Veterinarian Information
The gyri and sulci do not form normally, and so the brain surface is nearly smooth.
- Breeding Considerations
Affected animals should not be bred. Although little is known about the inheritance of this rare but devastating condition, it is best to avoid breeding parents or siblings of affected pups.
- Known Breeds Affected
Fox terrier, wire hair\nIrish setter\nLhasa apso
